4.2.2: Official Definition
4.X.X
[RFC3463] (Standards Track) from the The Internet Engineering Task Force (IETF) definition for codes that start with 4.X.X:
A persistent transient failure is one in which the message as sent is valid, but persistence of some temporary condition has caused abandonment or delay of attempts to send the message. If this code accompanies a delivery failure report, sending in the future may be successful.
X.2.2
[RFC3463] (Standards Track) from the The Internet Engineering Task Force (IETF) definition for codes that end with X.2.2:
The mailbox is full because the user has exceeded a per-mailbox administrative quota or physical capacity. The general semantics implies that the recipient can delete messages to make more space available. This code should be used as a persistent transient failure.