5.7.16: Official Definition
5.X.X
[RFC3463] (Standards Track) from the The Internet Engineering Task Force (IETF) definition for codes that start with 5.X.X:
A permanent failure is one which is not likely to be resolved by resending the message in the current form. Some change to the message or the destination must be made for successful delivery.
X.7.16
[RFC3463] (Standards Track) from the The Internet Engineering Task Force (IETF) definition for codes that end with X.7.16:
The message is too big for the specified priority. This condition might be temporary, for example the server is operating in a mode where only higher priority messages below certain size are accepted for transfer and delivery.